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Title
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Safe and Efficient Reductive Methylation of Primary and Secondary Amines Using N-Methylpyrrolidine Zinc Borohydride
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Type
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JournalPaper
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Keywords
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Amine; formaldehyde; reductive methylation; ZBHNMP
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Abstract
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An efficient, general procedure for reductive methylation of primary and secondary amines with 37% formaldehyde using N-methylpyrrolidine zinc borohydride (ZBHNMP) as a reducing agent gave the corresponding tertiary amines in excellent yields. The reaction was carried out in tetrahydrofuran under neutral conditions at 0–10 C
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Researchers
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Kazem Fazli (Fourth Researcher), Fatemeh Salehian (Third Researcher), mahmood tajbakhsh (Second Researcher), Heshmatollah Alinezhad (First Researcher)
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