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Title
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Ammonium Dihydrogen Phosphate Catalyst for One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones
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Type
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JournalPaper
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Keywords
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3,4-dihydropyrimidin-2-(1H)-one; ammonium dihydrogen phosphate; solvent free; condensation
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Abstract
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A one-pot three component Biginelli condensation of different substituted aromatic and aliphatic aldehydes with ethyl acetoacetate and urea to the respective 3,4-dihydropyrimidin-2-(1H)-ones under solvent-free conditions that is simple, effective, and environmentally friendly was shown. Ammonium dihydrogen phosphate (NH4H2PO4) was used as a non-toxic, inexpensive, and easily available catalyst. The facile reaction condition and simple isolation and purification procedures of this method make it a good option for the synthesis of dihydropyrimidinones.
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Researchers
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Malihe GHADAMGAHI (Third Researcher), Behrooz Maleki (Second Researcher), Reza Tayebee (First Researcher)
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