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Title
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Efficient synthesis of quinazoline derivatives catalyzed by flourinated alcohol
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Type
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JournalPaper
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Keywords
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Quinazoline , One-pot synthesis, 1,1,1,3,3,3-Hexafluoroisopropanol
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Abstract
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A facile and efficient protocol is reported for the synthesis of quinazoline derivatives via a one-pot multicomponent reaction of 2-amino-5-chlorobenzophenone, aromatic aldehydes and ammonium acetate using 1,1,1,3,3,3-hexafluoroisopropanol (HFIP). The use of HFIP both as the solvent and catalyst has significant advantages, including avoiding the use of an acidic catalyst and ease of product isolation.
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Researchers
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Akram Vedad Mofrad (Second Researcher), Behrooz Maleki (First Researcher)
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