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Title
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Lewis acid free synthesis of 3,4-dihydro-1H-indazolo[1,2-b]phthalazine-1,6,11(2H,13H)-triones promoted by 1,1,1,3,3,3-hexafluoro-2-propanol
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Type
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JournalPaper
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Keywords
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Lewis acid free synthesis of 3,4-dihydro-1H- indazolo[1,2-b]phthalazine-1,6,11(2H,13H)-triones 1,1,1,3,3,3-hexafluoro-2-propanol
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Abstract
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A convenient, environmentally friendly and efficient procedure for the synthesis 3,4-dihydro-1H-indazolo- [1,2-b]phthalazine-1,6,11(2H,13H)-trione derivatives has been developed via multi-component and one-pot reactions of various aldehydes with cyclic 1,3-diketones and phthalhydrazide 1,1,1,3,3,3-hexafluoro-2- propanol (HFIP). In simple and mild reaction conditions, the use of HFIP is explored as an easy workup and a green catalyst for the one-pot three-component synthesis of 3,4-dihydro-1H-indazolo[1,2-b]- phthalazine-1,6,11(2H,13H)-triones. Thus, this practical method is developed as a notable medium for these derivatives via a multicomponent reaction.
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Researchers
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Reza Tayebee (Third Researcher), Samaneh Sedigh Ashrafi (Second Researcher), Behrooz Maleki (First Researcher)
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