|
Title
|
Stereoselective Synthesis of Multifunctional Spirooxindole-Dihydrofuran Derivatives
|
|
Type
|
JournalPaper
|
|
Keywords
|
Isatin; multicomponent reaction; multifunctional spirooxindole-dihydrofurans; stereoselective synthesis
|
|
Abstract
|
A facile and efficient protocol for the diastereoselective synthesis of novel spirooxindole-dihydrofurans has been developed by the three-component condensation of isatin derivatives, 3-cyanoacetyl indole, and N-phenacylpyridinium bromide in the presence of triethylamine base. The reaction was carried out in ethanol under reflux conditions, and various dihydrofuranyl spirooxindoles were obtained in high yields with good to excellent stereoselectivity
|
|
Researchers
|
Razieh Azimi (First Researcher), Robabeh Baharfar (Second Researcher), Hashem Bagheri (Third Researcher)
|