09 بهمن 1401
ولي اله دبيدي روشن

ولی اله دبیدی روشن

مرتبه علمی: استاد
نشانی: دانشگاه
تحصیلات: دکترای تخصصی / علوم ورزشی (فیزیولوژی ورزشی)
تلفن: 011-35303400
دانشکده: دانشکده تربیت بدنی و علوم ورزشی

مشخصات پژوهش

عنوان Age-related effect of aerobic exercise training on antioxidant and oxidative markers in the liver challenged by doxorubicin in rats
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
Aerobic training; age; antioxidant status; heat shock protein; oxidative stress; toxicity
مجله Free Radical Research Communications
شناسه DOI /doi.org/10.1080/10715762.2018.1470328
پژوهشگران مهدی احمدیان (نفر اول) ، ولی اله دبیدی روشن (نفر دوم) ، آنتونی لیچت (نفر سوم)

چکیده

The aims of the current study were to investigate the oxidant and antioxidant status of liver tissue challenged by doxorubicin and to examine the possible protective effects of aerobic exercise on doxorubicin-induced oxidative stress. Seventy-two rats were divided into three age groups (Young, Adult, and Elderly) with three treatment subgroups consisting of eight rats per age group: doxorubicin, aerobic exerciseþdoxorubicin, and aerobic exerciseþsaline. The experimental groups performed regular treadmill running for 3 weeks. Doxorubicin was administered by i.p. injection at a dosage of 20mg kg1 while the aerobic exerciseþsaline group received saline of a comparable volume. Heat shock protein 70, malondialdehyde, glutathione peroxidase, and protein carbonyl were determined from the liver homogenates following the intervention period. Treatment with doxorubicin induced hepatotoxicity in all groups with lower values of oxidative stress in young compared with the older groups. The inclusion of aerobic exercise training significantly increased heat shock protein 70 and antioxidant enzyme levels (glutathione peroxidase) whereas it decreased oxidative stress biomarkers (malondialdehyde and protein carbonyl) for all age groups. These results suggest that aerobic exercise training may be a potential, non-drug strategy to modulate doxorubicin-induced hepatotoxicity through its positive impact on antioxidant levels and oxidative stress biomarkers.