January 29, 2023
Abbass Ghanbabri-Niaki

Abbass Ghanbabri-Niaki

Degree: Professor
Education: Ph.D in Exercise Physiology
Phone: 01135302218
Faculty: Faculty of Physical Education and Sports Sciences


Title The effects of high-intensity interval training on reverse cholesterol transport elements: A way of cardiovascular protection against atherosclerosis
Type Article
Cardioprotection, ATP-binding cassette transporter A1 (ABCA1), Liver X receptor (LXR), lecithin–cholesterol acyltransferase (LCAT), Scavenger receptor class b member 1 (SR-BI), Reverse cholesterol transport (RCT), High intensity interval training (HIIT)
Journal Life Sciences
DOI :10.1016/j.lfs.2018.08.036
Researchers Saleh Rahmati-Ahmadabad (First researcher) , Hossein Shirvani (Second researcher) , Abbass Ghanbabri-Niaki (Third researcher) , fateme rostamkhani (Fourth researcher)


Aims Reverse cholesterol transport (RCT) is a process that prevents atherosclerosis. Studies showed that exercise training for strenghthing cardiac muscle, increasing heart lipid metabolism and its potency against risk factors could protect cardiovascular health. Thus, the present study aims to investigate the effects of high intensity interval training (HIIT) on RCT and its related elements in plasma and tissues (liver and intestine) of rats. Materials and Methods Twenty adult male Wistar rats were randomly divided into control (n =10) and trained (n = 10) groups. The trained group undertook HIIT (90%-95% of VO2max, five days/week, for 10 weeks) on a treadmill. The rats were killed five days after the last training session to minimize the effects of the last training session. Key findings A higher and significant ABCA1 mRNA was observed in the liver and intestine of trained rats. However, ABCG1 and LXR expressions only increased in the liver following the HIIT. These changes in the expression of the trained rats were accompanied by higher changes in plasma LCAT and HDL levels. Significance The responses of ABCA1, as a key player in plasma HDL biogenesis, are similar in liver and intestine tissues after the HIIT program. However, different responses of ABCG1 and LXR in the liver and intestine tissues of the trained rats confirm the main role of the liver than the intestine in HDL biogenes. Therefore, HIIT modality result in cardiovascular protection by increasing the expression of genes involved in RCT and biogenesis of HDL.