January 29, 2023
Abbass Ghanbabri-Niaki

Abbass Ghanbabri-Niaki

Degree: Professor
Education: Ph.D in Exercise Physiology
Phone: 01135302218
Faculty: Faculty of Physical Education and Sports Sciences


Title Effects of endurance training and herb supplementation on tissue nesfatin-1/nucleobindin-2 and ghrelin mRNA expression
Type Article
Pistacia-atlantica (Bane), Aerobic training, Nesfatin-1, ghrelin, HDL-C, Treadmill, Estradiol
Journal International Journal of Applied Exercise Physiology
DOI 10.22631/ijaep.v6i1.118
Researchers Hossein Shirvani (First researcher) , Abbass Ghanbabri-Niaki (Second researcher) , Saleh Rahmati-Ahmadabad (Third researcher) , Vahid sobhani (Fourth researcher)


ABSTRACT: The aim of present study was to investigate the effects of aerobic training with and without Pistacia-atlantica (Bane) extraction as a plant rich in fatty acids, on rat tissues nesfatin-1/nucleobindin-2 and ghrelin gene expression and also on plasma lipid and lipoproteins profiles. Twenty healthy and intact Wistar rats were obtain and randomly were assigned into saline-control (SC), saline-training (ST), Bane-control (BC), and Bane-training (BT) groups. Training groups ran on a motor driven treadmill (at intensity 25m/min, 5days/wk.) for 8 weeks. Rats were orally received saline or bene solution (100 mg/kg and 7.5ul/g of body weight). Blood was collected to determine biochemical variables and liver and visceral fat were also obtain for Nesfatin-1/nucleobindin-2 and ghrelin mRNA expressions by using a Real-time PCR technique. A higher and significant nesfatin-1 mRNA expressions in liver and visceral fat and liver estradiol were observed in trained groups. However, the level of ghrelin expression was lower in trained groups when compared to control rats. In general, lower tissues nesfatin-1mRNA expression and lower plasma and higher estradiol HDL-C were observed in bane-treated rats. A negative and positive correlation between liver estradiol and liver ghrelin expression, plasma estradiol, HDL-C and visceral fat nesfatin-1 expression were found respectively. The results of present study indicate that exercise combined with bane-treatment induced considerable changes on liver and visceral fat nesfatin-1 and ghrelin expression which was accompanied with a significant change in plasma HDL-C as a cardiovascular risk factor.