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Zahra Ghanbari Masir

Zahra Ghanbari Masir

Academic rank: Assistant Professor
ORCID:
Education: PhD.
ScopusId:
Faculty: Faculty of Chemistry
Address:
Phone: 011-35305197

Research

Title
Current development of sigma-2 receptor radioligands as potential tumor imaging agents
Type
JournalPaper
Keywords
Small molecules Sigma-2 receptor Radiolabeling Imaging Cancer
Year
2021
Journal BIOORGANIC CHEMISTRY
DOI
Researchers Zahra Shaghaghi ، Maryam Alvandi ، Zahra Ghanbari Masir ، Soghra Farzipour ، Saeed Emami

Abstract

Sigma receptors are transmembrane proteins with two different subtypes: σ1 and σ2. Because of its overexpression in tumors, the σ2 receptor (σ2R) is a well-known biomarker for cancer cells. A large number of smallmolecule ligands for the σ2Rs have been identified and tested for imaging the proliferative status of tumors using single photon emission computed tomography (SPECT) and positron emission tomography (PET). These small molecules include derivatives of bicyclic amines, indoles, cyclohexylpiperazines and tetrahydroisoquinolines. This review discusses various aspects of small molecule ligands, such as chemical composition, labeling strategy, affinity for σ2Rs, and in vitro/in vivo investigations. The recent studies described here could be useful for the development of σ2R radioligands as potential tumor imaging agents.