Considering all physical, biological and social systems, fuzzy graph models serves the elemental processes of all natural and artificial structures. As the indeterminate information is an essential real-life problems, which are mostly uncertain, modeling those problems based on fuzzy graph is highly demanding for an expert. Vague graph can manage the uncertainty relevant to the inconsistent and indeterminate information of all real-world problems, in which fuzzy graphs possibly will not succeed into bringing about satisfactory results. Also, vague graphs are so useful tool to examine many issues such as networking, social systems, geometry, biology, clustering, and traffic plan. Hence, in this paper, we introduce strongly edge irregular vague graphs and strongly edge totally irregular vague graphs. A comparative study between strongly edge irregular vague graphs and strongly edge totally irregular vague graphs is done. Finally, we represent an application of irregular vague influence graph to show the importance of irregularity in vague graphs.