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Valiollah Dabidi Roshan

Valiollah Dabidi Roshan

Academic rank: Professor
ORCID: 0000-0002-2202-7349
Education: PhD.
ScopusId:
Faculty: Faculty of Physical Education and Sports Sciences
Address: university
Phone: 011-35302201

Research

Title
Taurine supplementation has antiatherogenic and anti-inflammatory effects before and after incremental exercise in heart failure
Type
JournalPaper
Keywords
anti-atherogenic; anti-inflammatory; exercise; heart failure; taurine
Year
2017
Journal Therapeutic Advances in Cardiovascular Disease
DOI
Researchers Mehdi Ahmadian ، Valiollah Dabidi Roshan ، elahe aslani ، Stephen R Stannard

Abstract

The purpose of this study was to examine the anti-atherogenic and anti-inflammatory effect of supplemental taurine prior to and following incremental exercise in patients with heart failure (HF). METHODS: Patients with HF and left ventricle ejection fraction less than 50%, and placed in functional class II or III according to the New York Heart Association classification, were randomly assigned to two groups: (1) taurine supplementation; or (2) placebo. The taurine group received oral taurine (500 mg) 3 times a day for 2 weeks, and performed exercise before and after the supplementation period. The placebo group followed the same protocol, but with a starch supplement (500 mg) rather than taurine. The incremental multilevel treadmill test was done using a modified Bruce protocol. RESULTS: Our results indicate that inflammatory indices [C-reactive protein (CRP), platelets] decreased in the taurine group in pre-exercise, post-supplementation and post-exercise, post-supplementation as compared with pre-exercise, pre-supplementation ( p < 0.05) whereas these indices increased in pre-exercise, post-supplementation and post-exercise, post-supplementation as compared with pre-exercise, pre-supplementation in the placebo group ( p < 0.05). Our results also show that atherogenic indices [Castelli's Risk Index-I (CRI-I), Castelli's Risk Index-II (CRI-II) and Atherogenic Coefficient (AC)] decreased in the taurine group in pre-exercise, post-supplementation and post-exercise, post-supplementation as compared with pre-exercise, pre-supplementation ( p < 0.05). No such changes were noted in the placebo group ( p > 0.05). CONCLUSIONS: our results suggest that 2 weeks of oral taurine supplementation increases the taurine levels and has anti-atherogenic and anti-inflammatory effects prior to and following incremental exercise in HF patients.