The present study aims to evaluate Cardioprotection effects of exercise training and curcumin on myocardial damage induced by lead acetate. Forty-eight rats were randomly divided into six groups of the base, sham, lead, exercise, curcumin and exercise+ curcumin (EC). The rats in the exercise and (EC) groups performed the progressive treadmill running of 15 to 22 m/min for 25 to 64 min, 5 times a week for 8 weeks. Lead, exercise, curcumin and (EC) groups received lead acetate (20 mg/kg), and sham, curcumin and (EC) groups received curcumin solvent (ethyloleat) and curcumin solution (30 mg/kg). Cardiac tissue was removed of aorta hiratus and homogenized for the estimation of troponin I, using ELISA. CK-MB and lead was determined in serum by immunological DGKE method and atomic absorption Spectrophotometry methods, respectively. Injection of lead acetate into intra-peritoneal resulted in a significant increase of the CK-MB levels. However, treadmill running exercise and curcumin supplementation resulted in a significant decrease of CK-MB levels while there was no significant difference in troponin I levels. The results of this study suggest the cardioprotective potential of administration of exercise and curcumin in ameliorating the lead-induced cardiotoxicity in rats through a decrease of myocardial damage markers
