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mahmood tajbakhsh

mahmood tajbakhsh

Academic rank: Professor
ORCID:
Education: PhD.
ScopusId:
Faculty: Faculty of Chemistry
Address: /Faculty of chemistry- University of Mazandaran- Babolsar- Iran
Phone: 09111146981

Research

Title
Diastereoselective sonochemical synthesis of spirocyclopropaneoxindoles and evaluation of their antioxidant and cytotoxic activities
Type
JournalPaper
Keywords
Spirocyclopropaneoxindoles، Three-component reactions، Ultrasonic irradiation، Antioxidant activities، Cytotoxicity activity
Year
2019
Journal Chemistry & Biodiversity
DOI
Researchers Maryam Pourshab ، Sakineh Asghari ، mahmood tajbakhsh ، Asieh Khalilpour

Abstract

An efficient diastereoselective synthesis of spirocyclopropaneoxindoles is reported using three-component reactions of various phenacylidenetriphenylphosphorane, isatins and phenacylbromide under ultrasonic irradiation. The structures of synthesized spirocyclopropaneoxindoles were characterized by their spectral data. The antioxidant activities of the synthesized compounds were evaluated by 1,1-diphenyl-2-picrylhydrazyl radical scavenging assay. Among the products those with NH group in their structure exhibited higher antioxidant activities than other derivatives. Also, In vitro cytotoxicity of compounds 4b,e,j,k were examined against HeLa cancer cell lines using MTT assay. The results revealed that compound 4j with chlorine substituent on phenyl group displayed higher cytotoxicity activity (IC50 = 4.50 ± 0.30 μg/mL) after 48 h.