2024 : 7 : 23
mahmood tajbakhsh

mahmood tajbakhsh

Academic rank: Professor
ORCID:
Education: PhD.
ScopusId:
Faculty: Faculty of Chemistry
Address: /Faculty of chemistry- University of Mazandaran- Babolsar- Iran
Phone: 09111146981

Research

Title
Five-component synthesis of dihydropyridines based on diketene
Type
JournalPaper
Keywords
Diketene, 1,4-dihydropyridines, Primary amine, Five-component reaction
Year
2017
Journal TETRAHEDRON
DOI
Researchers Atieh Rezvanian ، majid heravi ، zahra shaabani ، mahmood tajbakhsh

Abstract

A novelfive-component strategy involving commercially available diketene, primary amines, malono-nitrile and various benzaldehydes for the synthesis of densely functionalized 1,4-dihydropyridines in good yields was achieved. The reaction pathway involves a sequential ring-opening of diketene/enamine formation/Knoevenagel-condensation/Michael addition and 6-exo-tetcyclization, resulting in multiple bond-formation events including two CeC and three CeN bonds ultimately leading to the formation of the respective 1,4-dihydropyridines.