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mahmood tajbakhsh

mahmood tajbakhsh

Academic rank: Professor
ORCID:
Education: PhD.
ScopusId:
Faculty: Faculty of Chemistry
Address: /Faculty of chemistry- University of Mazandaran- Babolsar- Iran
Phone: 09111146981

Research

Title
New fluorescent sensor based on a calix[4]arene bearing two triazole–coumarin units for copper ions: application for Cu2+ detection in human blood serum
Type
JournalPaper
Keywords
Fluorescent sensor, Copper ion, Calix[4]arene, Coumarin units, Blood serum
Year
2019
Journal JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
DOI
Researchers Rahman Hosseinzadeh ، Elham Domehri ، mahmood tajbakhsh ، ahmadreza bekheradnia

Abstract

A novel fluorescent chemosensor calix[4]arene L, containing two fluorogenic coumarin units at the lower rim has been synthesized via click reaction. The structure of this chemosensor, was characterized by IR, NMR spectra and elemental analysis. Ion-binding properties of L were investigated in acetonitrile with different metal ions and the recognition process was monitored by fluorescence, UV-Vis and 1H NMR spectral changes. In comparison with other metal ions, chemosensor L showed a specific selectivity toward copper ions . The Job plot analysis revealed that the binding between L with Cu2+ is in 1:1 stoichiometry. The association constant (Ka) for the complex L.Cu2+ was found to be 1.6 × 105 M−1. The limit of detection of the sensor L was determined to be 5.4 × 10−7 M. This sensitive and selective chemosensor was successfully applied for the detection of Cu2+ ions in human blood serum with 90–100% recovery.