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mahmood tajbakhsh

mahmood tajbakhsh

Academic rank: Professor
ORCID:
Education: PhD.
ScopusId:
Faculty: Faculty of Chemistry
Address: /Faculty of chemistry- University of Mazandaran- Babolsar- Iran
Phone: 09111146981

Research

Title
A review on synthesis, mechanism of action, and structure-activity relationships of 1,2,3-triazole-based α-glucosidase inhibitors as promising anti-diabetic agents
Type
JournalPaper
Keywords
Diabetes α-Glucosidase 1,2,3-triazole Click reaction
Year
2022
Journal Journal of Molecular Structure
DOI
Researchers Zari Fallah ، mahmood tajbakhsh ، Majid Alikhani ، Bagher Larijani ، Mohammad Ali Faramarzi ، Haleh Hamedifar ، Maryam Mohammadi-Khanaposhtani ، Mohammad Mahdavi

Abstract

α-Glucosidase is a key enzyme in hydrolysis of carbohydrates to glucose and located in the small in- testine brush border. Inhibition of this enzyme delay the release of glucose and therefore α-glucosidase inhibitors are considered as attractive drugs for treatment of diabetes as a carbohydrate-related disor- der. Due to the importance of α-glucosidase inhibitors in the treatment of diabetes, the discovery and development of new safe and efficient inhibitors for α-glucosidase is an attractive topic for medicinal chemists. In the last decade, 1,2,3-triazole-based derivatives have found much interest in this research field. The click reaction is the most potent tool for easy construction for synthesis of hybrid molecules of 1,2,3-triazole ring and other effective pharmacophors in α-glucosidase inhibition. Herein, an overview is reported on synthesis, biological evaluations, and structure-activity relationships of the reported α- glucosidase inhibitors containing 1,2,3-triazole ring.