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mahmood tajbakhsh

mahmood tajbakhsh

Academic rank: Professor
ORCID:
Education: PhD.
ScopusId:
Faculty: Faculty of Chemistry
Address: /Faculty of chemistry- University of Mazandaran- Babolsar- Iran
Phone: 09111146981

Research

Title
Copper (II)-immobilized on Starch-coated Nanomagnetite as an Efficient and Magnetically Recoverable Catalyst for the Synthesis of Propargylamines through One-pot A<sup>3</sup> Coupling Reaction
Type
JournalPaper
Keywords
Catalyst
Year
2022
Journal Organic Preparations and Procedures International
DOI
Researchers mahmood tajbakhsh ، Fatemeh Mazhari ، Mohammad Mavvaji

Abstract

Propargylaminesareconsideredasessentialbuildingblocks for thesynthesisofnumerousbiologicallyactive compounds andnatural products includingb-lactams, peptides, andoxotremorineanalogues.1Fromthepharmaceuticalandtherapeuticaspects,propargylaminemoieties exhibit considerable activityas enzyme inhibitory,2 anti-HIV,3 anticancer,4 antibiotic,5 anti-Parkinson,6 anti-Alzheimer7 and anti-apoptotic8 agents. Moreover, theycanact impressivelyas synthetically fruitful intermediates toconstruct N-heterocycliccompounds, includingquinolones,9oxazoles,10pyrroles,11pyrrolidines,12 indolizines13andoxazolidinones.14,15Owingtothe importanceandutilityofpropargylamines, severalmethodshavebeenreportedfor theirpreparation. Inthis regard, traditional protocols comprise direct amination of propargylic halides, propargylic phosphonates, or propargylic triflates,16 aswell as thenucleophilic additionofmetal acetylidereagentstoiminesorenamines.17