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mahmood tajbakhsh

mahmood tajbakhsh

Academic rank: Professor
ORCID:
Education: PhD.
ScopusId:
Faculty: Faculty of Chemistry
Address: /Faculty of chemistry- University of Mazandaran- Babolsar- Iran
Phone: 09111146981

Research

Title
Synthesis of 1,4,5-Trisubstituted 1,2,3-Triazoles Through a One-Pot Three Component Reaction of Boronic Acids, Sodium Azide and Active Methylene Compounds Under Ball-Milling Conditions
Type
JournalPaper
Keywords
Active methylenes; ball-milling; boronic acids; one-pot reaction; 123-triazoles
Year
2022
Journal POLYCYCLIC AROMATIC COMPOUNDS
DOI
Researchers Rahman Hosseinzadeh ، Fatemeh Fathalipour ، mahmood tajbakhsh ، Mohammad Mavvaji ، Mona Pooryousef

Abstract

In this study, we report a mild and efficient one-pot synthesis of 1,4,5- trisubstituted 1,2,3-triazoles via a three-component reaction of aryl boronic acids with sodium azide and active methylene compounds under ball-milling condition. In order to determine optimized reaction conditions, several grinding auxiliaries (basic, neutral and acidic alumina, silica gel, K10 and KSF), bases (DBU, DABCO, piperidine, triethylamine, potassium t-butoxide and potassium carbonate) and copper salts under ballmilling conditions were examined. Using the optimized condition procedure, a wide variety of 1,4,5-trisubstituted 1,2,3-triazole derivatives were prepared in very good yields. All products were well-characterized by 1H-NMR and 13C-NMR spectroscopy. This environmentally friendly protocol offers several advantages including high yields of products, relatively short reaction time and simple work-up procedure.