1403/04/01
محمود تاجبخش

محمود تاجبخش

مرتبه علمی: استاد
ارکید:
تحصیلات: دکترای تخصصی
اسکاپوس:
دانشکده: دانشکده شیمی
نشانی:
تلفن: 09111146981

مشخصات پژوهش

عنوان
Five-component synthesis of dihydropyridines based on diketene
نوع پژوهش
JournalPaper
کلیدواژه‌ها
Diketene, 1,4-dihydropyridines, Primary amine, Five-component reaction
سال
2017
مجله TETRAHEDRON
شناسه DOI
پژوهشگران Atieh Rezvanian ، majid heravi ، zahra shaabani ، mahmood tajbakhsh

چکیده

A novelfive-component strategy involving commercially available diketene, primary amines, malono-nitrile and various benzaldehydes for the synthesis of densely functionalized 1,4-dihydropyridines in good yields was achieved. The reaction pathway involves a sequential ring-opening of diketene/enamine formation/Knoevenagel-condensation/Michael addition and 6-exo-tetcyclization, resulting in multiple bond-formation events including two CeC and three CeN bonds ultimately leading to the formation of the respective 1,4-dihydropyridines.