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Sakineh Asghari

Sakineh Asghari

Academic rank: Professor
ORCID:
Education: PhD.
ScopusId:
HIndex:
Faculty: Faculty of Chemistry
Address: Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran
Phone: 01135302357

Research

Title
Three-component synthesis and antibacterial evaluation of some novel 1,2-dihydroisoquinoline derivatives
Type
JournalPaper
Keywords
Kojic acid, 8-Hydroxyquinolone, Dialkyl acetylenedicarboxylates, 1,2-Dihydroisoquinoline, Isoquinoline, Antibacterial activity
Year
2014
Journal CHINESE CHEMICAL LETTERS
DOI
Researchers Sakineh Asghari ، nastaran malekian ، Roya Esmaeilpour ، mohammad ahmadipour ، Mojtaba Mohseni

Abstract

Isoquinoline reacts with dialkyl acetylenedicarboxylates in the presence of kojic acid or 8-hydroxyquinoline to generate 1,2-dihydroisoquinoline derivatives. The simplicity, mild reaction conditions and high yields of products make it an interesting process compared to other approaches. The compounds have been analyzed for antibacterial activity against Gram negative and Gram positive bacteria. The results indicated that 1,2-dihydroisoquinolines derived from kojic acid are effective against all of the studied bacteria especially against Bacillus subtilis, while the products obtained from 8-hydroxyquinoline are active only against Gram positive bacteria.