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Yaghoub Sarrafi

Yaghoub Sarrafi

Academic rank: Professor
ORCID:
Education: PhD.
ScopusId:
Faculty: Faculty of Chemistry
Address:
Phone: 9121978350

Research

Title
α-Glucosidase inhibitory and antioxidant activity of furanocoumarins from Heracleum persicum
Type
JournalPaper
Keywords
Heracleum persicumα-Glucosidase inhibitionDPPHFuranocoumarinMoellendorffiline
Year
2017
Journal MEDICINAL CHEMISTRY RESEARCH
DOI
Researchers Hossein Dehghan ، Yaghoub Sarrafi ، Peyman salehi ، Samad Nejad Ebrahimi

Abstract

As a part of ongoing project on biological screening of about a hundred plant extracts from Iran, the significant inhibitory effect of n-hexane extract of roots of Heracleum persicum on α-glucosidase and its 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity were revealed. The present study was designed to evaluate the antidiabetic and antioxidant activities of various extracts of roots of Heracleum persicum and isolation of ten furanocoumarin and a rare furanocoumarin-dimer type compounds through “bioassay guided fractionation” method. The structures were elucidated by 1D and 2D NMR, EI-MS, and HRESI-MS data as psoralen (1), bergapten (2), xanthotoxin (3), isopimpinellin (4), angelicin (5), isobergapten (6), sphondin (7), pimpinellin (8), heratomin (9), 5-methoxyheratomin (10), moellendorffiline (11), and fraxetin (12). Moellendorffiline (11) with the IC50 value of 17.9 nM showed significant inhibitory activity against α-glucosidase, more potent than acarbose (IC50 = 23.5 nM) and also exhibited high antioxidant activity (IC50 = 0.2 μM), compared with butylated hydroxytoluene (IC50 = 0.1 μM)