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Yaghoub Sarrafi

Yaghoub Sarrafi

Academic rank: Professor
ORCID:
Education: PhD.
ScopusId:
Faculty: Faculty of Chemistry
Address:
Phone: 9121978350

Research

Title
An expedient approach for the regio- and stereoselective synthesis of novel spiroindolizidines via [3+2] cycloaddition
Type
JournalPaper
Keywords
1,3-Dipolar cycloaddition; Azomethine ylide; Indolizidines; Spiro compounds; 1,5-Prototropic shift
Year
2014
Journal COMPTES RENDUS CHIMIE
DOI
Researchers Kamal Alimohammadi ، Yaghoub Sarrafi ، Bahareh Rajabpour

Abstract

A new series of spiroindolizidines was synthesized by one-pot, three-component condensation of azomethine ylides, generated from 1,2,3,4-tetrahydroisoquinoline with ninhydrin or isatin derivatives by a 1,5-prototropic shift route, with various derivatives of trans-β-nitrostyrene in a regio- and stereoselective manner. X-ray crystal structure analysis and NMR spectroscopic data confirmed the structure outcome of the cycloaddition reaction