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Yaghoub Sarrafi

Yaghoub Sarrafi

Academic rank: Professor
ORCID:
Education: PhD.
ScopusId:
Faculty: Faculty of Chemistry
Address:
Phone: 9121978350

Research

Title
A new series of Schiff base derivatives bearing 1,2,3-triazole: Design, synthesis, molecular docking, and α-glucosidase inhibition
Type
JournalPaper
Keywords
1,2,3‐triazole, antidiabetic activity, molecular docking, Schiff base, α‐glucosidase
Year
2019
Journal ARCHIV DER PHARMAZIE
DOI
Researchers Ensieh Nasli-Esfahani ، Maryam Mohammadi-Khanaposhtani ، Sepideh Rezaei ، Yaghoub Sarrafi ، Zeinab Sharafi ، Nasser Samadi ، Mohammad Ali Faramarzi ، Fatemeh Bandarian ، Haleh Hamedifar ، Bagher Larijani ، Mirhamed Hajimiri ، mohammad mahdavi

Abstract

A series of new Schiff bases bearing 1,2,3-triazole 12a‒o was designed, synthesized, and evaluated as α-glucosidase inhibitors. All the synthesized compounds showed promising inhibition against α-glucosidase and were more potent than the standard drug acarbose. The kinetic study on the most potent compound 12n showed that this compound acted as a competitive α-glucosidase inhibitor. The docking study revealed that the synthesized compounds interacted with the important residues in the active site of α-glucosidase.