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َAbdolraouf Samadi-Maybodi

Academic rank: Professor
ORCID:
Education: PhD.
ScopusId:
Faculty: Faculty of Chemistry
Address:
Phone: 011-35302396

Research

Title
Comprehensive study of loading and release of sodium valproate drug molecule from functionalized SBA-15 with aminopropyl groups through Co-condensation modification method
Type
JournalPaper
Keywords
SBA-15; Box-Behnken design; Sodium valproate; Drug loading; Drug release
Year
2020
Journal MATERIALS CHEMISTRY AND PHYSICS
DOI
Researchers َAbdolraouf Samadi-Maybodi ، Edris Sedighi-Pashaki

Abstract

Mesoporous Santa Barbara amorphous (SBA-15) was functionalized through co-condensation using tetraethoxy orthosilicate and 3-aminopropyltriethoxysilane in the presence of the copolymer Pluronic P-123 (EO20PO70EO20) as a pore-directing agent under an acidic condition. A comprehensive study of the sodium valproate (SV) loading and release was carried out on SBA-15 and functionalized SBA-15. The functionalized and drug loaded mesoporous materials were comprehensively characterized using X-ray diffraction, nitrogen adsorption isotherms, FTIR, TGA, SEM, and TEM techniques. The Box-Behnken design was applied to optimize the variables of drug loading time, ultrasound irradiation time, and carrier dose. Results indicated that the COO