We collected daily non-accidental mortality and data on air pollutants and weather conditions from Tehran, Iran, 2012–2016. A quasi-Poisson or Gaussian time-series regression was employed to fit the associations between ambient PM2.5 and mortality or YLL. Potential gains in life expectancy (PGLE) and attributable fraction (AF) were estimated by assuming that daily PM2.5 concentrations attained the World Health Organization air quality guidelines (WHO AQG) 2005 (25 μg/m3) and 2021 (15 μg/m3).