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Rahman Hosseinzadeh

Rahman Hosseinzadeh

Academic rank: Professor
ORCID:
Education: PhD.
ScopusId:
HIndex:
Faculty: Faculty of Chemistry
Address: Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran
Phone: 01135302356

Research

Title
Simultaneous determination of droxidopa and carbidopa by carbon paste electrode functionalized with NiFe2O4 nanoparticle and 2-(4-ferrocenyl-[1,2,3]triazol-1-yl)-1-(naphthalen-2-yl) ethanone
Type
JournalPaper
Keywords
Droxidopa; NiFe2O4 nanoparticles; Chemical modified electrodes; Carbidopa
Year
2020
Journal MEASUREMENT
DOI
Researchers Sayed Zia Mohammadi ، Hadi Beitollahi ، Massoud Kaykhaii ، Nosrat Mohammadizadeh ، Somayeh Tajik ، Rahman Hosseinzadeh

Abstract

Droxidopa is a prescribed medication for the treatment of orthostatic hypertension in patients with pure autonomic failure and multiple system atrophy, which causes symptoms of lightheadedness and Parkinson’s disease. In the current study, a simple electrochemical sensor designed for simultaneously determination of droxidopa and carbidopa via using 2-(4-ferrocenyl-[1,2,3]triazol-1-yl)-1-(naphthalen2-yl) ethanone (2FTNE) modified NiFe2O4 nanoparticles paste electrode (2FTNENFOCPE). The 2FTNENFOCPE exhibited exceptional electrochemical catalytic behavior against droxidopa and carbidopa. Chronoamperometry, cyclic voltammetry and differential pulse voltammetry (DPV) were used to explore the analytical performance of 2FTNENFOCPE for co-detection of droxidopa and carbidopa. The 2FTNENFOCPE is able to separate oxidation peak potentials of droxidopa and carbidopa about 440 mV. The detection limits achieved via DPV, for droxidopa and carbidopa were 6.0  108 and 3.0  107 M. In the final, the 2FT