2024 : 7 : 16
Rahman Hosseinzadeh

Rahman Hosseinzadeh

Academic rank: Professor
ORCID:
Education: PhD.
ScopusId:
Faculty: Faculty of Chemistry
Address: Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran
Phone: 01135302356

Research

Title
Catalyst-Free One-Pot Reductive Alkylation of Primary and Secondary Amines and N,N-Dimethylation of Amino Acids Using Sodium Borohydride in 2,2,2-Trifluoroethano
Type
JournalPaper
Keywords
reductive amination - 2,2,2-trifluoroethanol - sodium borohydride - reductive methylation
Year
2010
Journal SYNTHESIS
DOI
Researchers mahmood tajbakhsh ، Rahman Hosseinzadeh ، Heshmatollah Alinezhad ، Somayeh Ghahari ، akbar heydari ، samad khaksar

Abstract

A simple and convenient procedure for the reductive alkylation of primary and secondary amines and N,N-dimethylation of amino acids is described using sodium borohydride as a reducing agent in 2,2,2- trifluoroethanol without use of a catalyst or any other additive. The solvent can be readily recovered from reaction products in excellent purity for direct reuse.