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Rahman Hosseinzadeh

Rahman Hosseinzadeh

Academic rank: Professor
ORCID:
Education: PhD.
ScopusId:
Faculty: Faculty of Chemistry
Address: Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran
Phone: 01135302356

Research

Title
Electroanalysis and Simultaneous Determination of 6-Thioguanine in the Presence of Uric Acid and Folic Acid Using a Modified Carbon Nanotube Paste Electrode
Type
JournalPaper
Keywords
Electroanalysis ,6-Thioguanine, Folic Acid, Uric Acid
Year
2011
Journal ANALYTICAL SCIENCES
DOI
Researchers Hadi Beitollahi ، Jahan Bakhsh Raoof ، Rahman Hosseinzadeh

Abstract

The present work describes the preparation and characterization of a carbon nanotube paste electrode modified with 2,7-bis(ferrocenyl ethyl)fluoren-9-one (2,7-BF). This electrode showed an efficient catalytic activity for the electro-oxidation of 6-thioguanine (6-TG), which leads to lowering 6-TG overpotential by more than 610 mV. Also, the values of catalytic rate constant (k = 2.7 × 10 3mol –1L s –1 ), and diffusion coefficient (D = 2.7 × 10 –5 cm2 s) were calculated. In 0.1 M phosphate buffer solution of pH 7.0, the oxidation current increased linearly with two concentration intervals of 6-TG, one is 0.06 to 10.0 μmol L–1 and the other is 10.0 to 160.0 μmol L–1 . The detection limit (3σ) obtained by differential pulse voltammetry (DPV) was 22.0 nmol L–1 . DPV was used for simultaneous determination of 6-TG, uric acid (UA) and folic acid (FA) at the modified electrode, and for quantification of 6-TG, UA and FA in some real samples by the standard addition method.