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Rahman Hosseinzadeh

Rahman Hosseinzadeh

Academic rank: Professor
Education: PhD.
Faculty: Faculty of Chemistry
Address: Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran
Phone: 01135302356


A new fluorescent boronic acid sensor based on carbazole for glucose sensing via aggregation induced emission
Fluorescent sensor, Carbazole, Glucose, Boronic acid
Journal RSC Advances
Researchers Mandana Oloub ، Rahman Hosseinzadeh ، mahmood tajbakhsh ، Maryam Mohadjerani


A water-soluble fluorescent sensor based on carbazole pyridinium boronic acid (CPBA) was designed and synthesized. Its structure has been confirmed by CHN and 1H and 13C NMR, FT-IR, and MS spectral data. Fluorescence studies of the synthesized chemosensor CPBA showed a selective ratiometric fluorescent response for glucose among different monosaccharides. The results specified that CPBA is a pH sensitive sensor that behaves differently in the absence and presence of glucose in the pH range 4–10. The pH, DLS, Job's plot, UV-visible, and fluorescence titration studies showed that the selectivity of CPBA towards glucose is through the aggregation-induced emission (AIE) phenomenon. The fluorescence emission intensity of CPBA changes by more than 2100 fold by adding glucose, whereas it is 2 fold for fructose. The calculated binding constant value of CPBA for glucose (K ¼ 2.3  106 M1) is 85 times greater than for fructose, indicating the high affinity of the sensor for glucose.