The elasticity of the skin and collagen fibers in the epidermis and dermis gradually decreases which is called aging. The characteristics of aging include wrinkles, dryness and pigmentation. Generally, three groups of the genes are involved in skin aging including antioxidant capacity, elasticity, hydration. Defects in any of these genes cause wrinkles on the skin. Oxygen free radicals in the skin causes oxidative stress, one of the main causes of collagen and elastin destruction, which ultimately leads to wrinkles and sagging skin. One of the antioxidant genes is the catalase gene, which plays an important role in converting free radicals into inert molecules. In this study we exhibited the association among the genes involving the human skin aging as well as their connections with CAT gene by creating a gene network. Materials and methods The genes related to hydration, antioxidant capacity and skin elasticity were systematically collected by literature review. The gene network was created by GeneMANIA algorithm based on protein-protein interaction, genetic interaction, co-localization and pathway. Result: We found 56 genes related to skin aging . Catalase is connected to MNSOD2, ALDH1A1, PCNA and CYP1A1 genes. Likewise, we observed JUN gene has the most biological connections with the other skin aging genes. Conclusions This study shows catalase gene in addition to antioxidant activity may also involve in skin aging and introduce JUN genes as important gene in skin aging. Our study provides insight about the prioritization of the genes are involving in skin aging.
