Presbycusis, a Greek word meaning "senile hearing", refers to age-related hearing loss. This complication is caused by several factors, including physiological and anatomical changes due to aging, genetic predispositions, hormonal effects, etc. In this research, a systematic review was conducted using advanced search in PubMed to identify genes related to Presbycusis. Articles were selected for analysis based on statistically significant relationship (p-value <0.05) between the genes and Presbycusis. The purpose of this study is to better understand genetic factors and genes affecting hearing loss associated with Presbycusis. Based on the findings of our systematic review, 78 genes related to Presbycusis were identified and the gene network was drawn. The analysis of 12 different methods of identifying key genes (hub gene) by the GeneMANIA algorithm showed that among 78 genes, PTK2, GRM7, CTH, DCLK1 and TLR4 genes were identified 10, 10, 9, 8 and 8 times by different methods, respectively as hub genes. The frequent presence of these genes as hub gene shows that they are the most important genetic factors affecting Presbycusis. These findings have contributed to the better understanding of the most important genetic factors affecting Presbycusis and inspiring for research in the treatment of Presbycusis and targeting these key genes to treat this disease.
