Shaykh Ṣadūq has his specific methods and criteria for semantic analysis of the Gharīb (unfamiliar) terms in the field of hadith in general, and in the area of interpretation and semantics of vocabulary in particular; recognizing his methods and criteria in the semantic analysis of Gharīb words in the Holy Quran and the sayings of the impeccable Imams (AS) leads to the discovery of new approaches and the presentation of a more precise image of his methods and criteria in semantic analysis. Among his remaining works, one can find some of his views. The present study aims to observe and discover the types of explanations of Gharīb words in the thoughts of Shaykh Ṣadūq. To this aim was used a descriptive-analytical method and data collection is library-based. The result indicated that he used methods such as: Utilizing Shia theological arguments, defining examples for words, leveraging Arabic culture and literature, interpreting Gharīb words according to the companions, followers of the Imams (AS), and his scholars, highlighting grammatical points, using the sayings of the impeccable Imams (AS), stating all semantic aspects of a word, and preferring one meaning over others. Through his specific criteria, Shaykh Ṣadūq has been able to reach the core meaning and interpretive significance of Gharīb words.