An important group of ligands in coordination chemistry is called Schiff base in which have wide application in various fields of science. Metal complexes of these ligands attract a great attention due to their simple preparation, vast application, steric and electronic properties. Schiff base ligands can be easily coordinate many various metals to stabilize them at different oxidation states [1,2]. Many Schiff base and their complexes are considerably interest due to their biological activity such as antibacterial, antifungal, antitumor, antimalarial, antineoplastic and antiviral activities [3]. It has been suggested that in such compounds of the azomethine group is responsible for the biological activity [4]. During the later half of the century, a number of different classes of antibacterial agents have been discovered. At the present time, antibacterial sulfa drugs, nitrosulfa, cephalosporins, macrolides, nitrofuranes, penicillins, tetracyclines, oxaolidinones indicate antimicrobial activity [5]. It is demonstrated that more than 70% of bacterial infections are resistant to one or some antibiotics used for eradication the infection. It is necessary to search more effective antimicrobial agents and some Schiff bases have been known as promising antimicrobial agents.
