In this research, having applied the modeling of D/3He fuel burning, the isentropic parameter and entropy are studied. It is shown that the Fermi degeneracy plays an important role in reducing the pressure, energy driver and the fractional burn-up. Based on recent progresses in the laser particle accelerators’ research, we have examined the ignition of a D/3He fuel to achieve the gains of order 58. The obtained results show that the energy required to compress a D/3He fuel with a density of 3.9×104 g/cm3, is 3.3 × 107 J/g. With the confinement parameter, 80 g/cm2 and a two times reduction of the isentropic parameter, the increased rate of the target gain is 31%
