Environmental pollutants, such as phenols and their derivatives are one of the most serious concerns that the world is facing and is considered a long-term threat to human development [1]. Given the harmful effects of this compounds, including chlorophenols (CPs) and aminophenols (APs), on human and animal health, many efforts have been made to various analytical methods for detection and measurement. Among the various reported methods for measuring environmental pollutants, electrochemical methods have received more attention than other methods [2]. The electrochemical methods have several advantages, including higher sensitivity, rapid measurement mechanisms with low limits of detection (LODs), fast reaction times, and simple and portable equipment for on-site application [3]. Herein, we designed a novel electrochemical sensor based on carbon paste electrode modified with polyoxometalates@carbon spheres-multiwalled carbon nanotubes and β-cyclodextrin composite (H3PW12O40@CS-MWCNTs-βCD/CPE) for simultaneous determination of some phenolic compounds. In this method, differential pulse voltammetry was used to detect both 2-AP and 4-CP in environmental samples. Consequently, the differential pulse voltammetry displayed a wide two-step linear dynamic range (0.005-0.100 µM and 5-100 µM) with limits of detection (LODs) values ranging from 0.0014-0.0017 µM under optimal condition. The electrochemical sensor exhibited excellent electrochemical performance, low LOD, wide LDR, high stability for simultaneous detection of 2-AP and 4-CP. Furthermore, the constructed electrochemical sensor showed good recovery percentage (97–112%) for 2-AP and 4-CP in different water samples. Therefore, the prepared electrochemical sensor has demonstrated excellent simultaneous analysis of 2-AP and 4-CP in various water samples.
