Introduction: Alzheimer disease is a type of dementia that causes memory, thinking and behavioral problems that usually starts slowly and gets worse over time. Methionine synthase (MTR) is a gene involved in folate metabolism which may contribute to the risk of Alzheimer disease (AD). In this study, we investigated the association of MTR A2756G gene transition with AD in a case-control study. Materials and Methods: The 171 samples consist of 85 patients with Alzheimer disease as case group and 86 healthy controls included in this study. MTR A2756G genotyping was performed by PCR-CTPP techniques. SPSS software and Oege online web analyzer were used to statistical analysis. Result: Our data showed that the AG genotype (with OR: 0.762, 95% CI: 0.39-1.49, p= 0.429), GG genotype (with OR: 0.767, 95% CI: 0.24-2.43, p= 0.652), and G allele (with OR: 0.966, 95% CI: 0.58-1.62, p= 0.895) were not associated with Alzheimer disease. Conclution: Based on the results, determining the genotype of MTR- A2756G transition may not be a useful molecular marker to screen susceptible individuals for Alzheimer disease. However, further studies with larger sample sizes and different ethnicity were required to obtain more accurate data.
