The presbycusis disorder refers to age-related hearing loss, and damage in the cytochrome P4501A (CYP1A1) gene can contribute to increasing the risk of this disease. CYP1A1 enzyme gene has different polymorphisms, rs4646903 and rs1048943 polymorphisms are common types of these varieties. Therefore, the aim of this study is to investigate the relationship between the mentioned polymorphisms and the risk of presbycusis with a meta-analysis approach. For this purpose, related articles published before January 2023 were collected by searching PubMed, Google Scholar, Scopus and Web of Sciences databases in English using the following keywords: ("polymorphism" or "Single nucleotide polymorphism " or "SNP" or "mutation") and ("presbycusis" or "Age-related Hearing Loss") and ("CYP1A1" or "Cytochrome P4501A1") and ("rs4646903") and ("rs1048943"). Analysis of polymorphisms showed that there is a significant relationship between rs1048943 polymorphism and increased risk of the presbycusis in the homozygous model (OR: 1.75, 95%CI: 1.08-2.84, P-value: 0.023). However, there was no significant relationship between rs4646903 polymorphism and the presbycusis risk. According to the present results, rs4646903 polymorphism may be considered as a molecular risk factor of the presbycusis disorder.
