1403/01/09
محمد کریمیان

محمد کریمیان

مرتبه علمی: استادیار
ارکید:
تحصیلات: دکترای تخصصی
اسکاپوس:
دانشکده: دانشکده علوم پایه
نشانی:
تلفن: 01135302401

مشخصات پژوهش

عنوان
G-Protein-Coupled Receptors and Ischemic Stroke: a Focus on Molecular Function and Therapeutic Potential
نوع پژوهش
JournalPaper
کلیدواژه‌ها
Ischemic stroke, G-protein-coupled receptors, Cell signaling, Therapeutic targets
سال
2021
مجله MOLECULAR NEUROBIOLOGY
شناسه DOI
پژوهشگران Zeinab Vahidinia ، Mohammad Taghi Joghataei ، Cordian Beyer ، Mohammad Karimian ، Abolfazl Azami Tameh

چکیده

In ischemic stroke, there is only one approved drug, tissue plasminogen activator, to be used in clinical conditions for thrombolysis. New neuroprotective therapies for ischemic stroke are desperately needed. Several targets and pathways have been shown to confer neuroprotective effects in ischemic stroke. G-protein-coupled receptors (GPCRs) are one of the most frequently targeted receptors for developing novel therapeutics for central nervous system disorders. GPCRs are a large family of cell surface receptors that response to a wide variety of extracellular stimuli. GPCRs are involved in a wide range of physiological and pathological processes. More than 90% of the identified non-sensory GPCRs are expressed in the brain, where they play important roles in regulating mood, pain, vision, immune responses, cognition, and synaptic transmission. There is also good evidence that GPCRs are implicated in the pathogenesis of stroke. This review narrates the pathophysiological role and possible targeted therapy of GPCRs in ischemic stroke.