We study cosmological Lemaitre–Tolman–Bondi (LTB) black hole thermodynamics immersed in a quintom universe. We investigate some thermodynamic aspects of such a black hole in detail.We apply two methods of treating particles’ tunneling from the apparent horizons and calculate the black hole’s temperature in each method; the results of which are the same. In addition, by considering specific time slices in the cosmic history, we study the thermodynamic features of this black hole in these specific cosmic epochs. Also, we discuss the information loss problem and the remnant content of the cosmological black hole in different cosmic epochs in this context.We showthat approximately in all the cosmic history, the temperature of the black hole’s apparent horizon is more than the temperature of the cosmological apparent horizon.