In this paper, we probe in 4D Einstein–Gauss– Bonnet black hole and its thermodynamics.We illustrate the three asymptotically 4DEGBspacetime as an asymptotically flat, de Sitter, and Anti-de Sitter. Also,we apply the tunneling of the massless particles from the horizon of 4D EGB gravity and we investigate the correlation between the emission modes and temperature of the horizon. In asymptotically flat spacetime, the existence of the coupling constant alone constructs the regular spacetime, the radiation deviates from the pure thermal, and the temperature of the black hole horizon would be zero in the final stage of the black hole evaporation. In Asymptotically de Sitter spacetime, results illustrate that the evolution of the temperatures is in direction of the remaining rest mass with the probably same temperature for the black hole and the cosmological horizon. In addition, the exciting result is that temperature behaviors exactly match with the temperature behaviors of a regular black hole in Lovelock gravity in a higher dimension.