The electrooxidation ofD-penicillamine (D-PA) was studied in the presence of ferrocyanide as a homogeneous mediator at the surface of a carbon paste electrode in aqueous media using cyclic voltammetry (CV) and chronoamperometry. Under optimum pH in CV the oxidation of D-PA occurs at a potential about 380 mV less positive than that in the absence of ferrocyanide. The catalytic oxidation peak current was dependent on the D-PA concentration and a linear calibration curve was obtained in the ranges 4.0910-5–2.0910-3 M and 8.0910-6–1.8910-4 MofD-PA with CV and differential pulse voltammetry (DPV) methods, espectively. The detection limits (3r) were determined as 1.9910-5and 3.2910-6 M by CV and DPV methods. This method was also used for the determination ofD-PA in pharmaceutical preparations by the standard addition method.
