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Hamid Golchoubian

Hamid Golchoubian

Academic rank: Professor
ORCID: ORCID ID: 0000-0001-9794-4187
Education: PhD.
ScopusId: 14009200600
Faculty: Faculty of Chemistry
Address:
Phone: 01135302385

Research

Title
Guanidine hydrochloride as an organocatalyst for N-Boc protection of amino groups
Type
JournalPaper
Keywords
Protection, Organocatalysis, (Boc)2O, Amines, Amino acids
Year
2011
Journal Tetrahedron Letters
DOI
Researchers Hamid Golchoubian ، Fatemeh Jahani Bahnamiri ، mahmood tajbakhsh ، samad khaksar

Abstract

A simple and efficient method for the chemoselective N-Boc protection of the amine moiety in a variety of compounds is described using di-tert-butyl dicarbonate and guanidine hydrochloride as an organocatalyst in ethanol at 35–40 C. Selective mono-N-Boc protection of diamines and chemoselective protection of hydroxylamines without formation of any side products is achieved. Amino acids and peptides are N-Boc protected efficiently in excellent yields under convenient reaction conditions.