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Heshmatollah Alinezhad

Heshmatollah Alinezhad

Academic rank: Professor
ORCID:
Education: PhD.
ScopusId:
Faculty: Faculty of Chemistry
Address:
Phone: 9111144735

Research

Title
One-Pot Synthesis of Polyhydroquinolines Catalyzed by ZnCl2 Supported on Nano Fe3O4@SiO2
Type
JournalPaper
Keywords
hypertension treatments,1,4-dihydropyridine
Year
2019
Journal ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL
DOI
Researchers Behrooz Maleki ، Heshmatollah Alinezhad ، Hengameh Atharifar ، Reza Tayebee ، Akram Vedad Mofrad

Abstract

The development of an atom-economical approach for the efficient construction of diversely functionalized molecules from easily accessible starting materials is always a special issue for synthetic organic chemists The 4-substituted 1,4-dihydropyridine (1,4-DHP) nucleus is a rich source of biological molecules which are useful as antihypertensive, vasodilator, antitherosclerotic, antitumor, geroprotective and antidiabetic agents. These compounds also have activities as neuroprotectants and as platelet anti-aggregants. They have cerebral antischaemic activity in the treatment of Alzheimer’s disease and chemosensitizer behavior in tumor therapy The valuable cardiovascular agents nifepidin, felodipine and amlodipine belong to this category of compounds, and they play important roles in hypertension treatments.10 They have shown usefulness in the treatment of angina pectoris and other cardiovascular diseases