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Heshmatollah Alinezhad

Heshmatollah Alinezhad

Academic rank: Professor
ORCID:
Education: PhD.
ScopusId:
Faculty: Faculty of Chemistry
Address:
Phone: 9111144735

Research

Title
magnetic solid-phase extraction of non-steroidal anti-inflammatory drugs from environmental water samples using polyamidoamine dendrimer functionalized with magnetite nanoparticles as a sorbent
Type
JournalPaper
Keywords
Non-steroidal anti-inflammatory drugs Magnetic solid-phase extraction Polyamidoamine Liquid chromatography Water sampl
Year
2018
Journal TALANTA
DOI
Researchers Heshmatollah Alinezhad ، amirhassan amiri ، mehrasa tarahomi ، Behrooz Maleki

Abstract

A novel polyamidoamine dendrimer functionalized with Fe3O4 nanoparticles (Fe3O4@PAMAM) had been fabricated and used as magnetic solid-phase extraction (MSPE) adsorbent. The Fe3O4@PAMAM nanocomposites were characterized by X-ray powder diffraction, Fourier transform infrared spectroscopy, field-emission scanning electron spectroscopy, elemental analytical, and thermal gravimetric analysis. The MSPE method coupled with high-performance liquid chromatography with an ultraviolet detection system was applied for the separation/analysis of non-steroidal anti-inflammatory drugs (NSAIDs). Major parameters affecting the extraction efficiency of the selected drugs were optimized. Under optimal conditions, the enrichment factors for the proposed method were 701e835. The linear range, limit of detection, correlation coefficient (r), and relative standard deviation (RSD) were found to be 0.15–500 ng mL−1 , 0.05e0.08 ng mL−1 , 0.9932e0.9967, and 4.5–7.0% (n = 5, 0.2, 10 and 300 ng mL−1 ), respectively. The method was successfully applied to the determination of NSAIDs in the real water samples. The recoveries of spiked water samples were in the range of 93.6–98.9% with RSDs varying from 6.1% to 9.0%, showing the good accuracy of the method