Synthesis of Novel Benzo[6,7][1,4]oxazepino[4,5-a]quinazolinone Derivatives via Transition-Metal-Free Intramolecular Hydroamination

Research

Title	Synthesis of Novel Benzo[6,7][1,4]oxazepino[4,5-a]quinazolinone Derivatives via Transition-Metal-Free Intramolecular Hydroamination
Type	JournalPaper
Keywords	hydroamination, 2-aminobenzamides, terminal alkynes, 7-exo-dig, N-heterocycles
Year	2014
Journal	SYNLETT
DOI
Researchers	Mohammad Mahdavi ، Niloufar Foroughi ، Mina Saeedi ، Maryam Karimi ، Heshmatollah Alinezhad ، Alireza Foroumadi ، Abbas Shafiee ، Tahmineh Akbarzadeh

Abstract

Novel benzo[6,7][1,4]oxazepino[4,5-a]quinazolinone derivatives were synthesized through an efficient 7-exo-dig hydroamination of 3-substituted-2-[2-(prop-2-yn-1-yloxy)phenyl]- 2,3-dihydroquinazolin-4(1H)-ones in the presence of potassium tert-butoxide (KOt-Bu) in DMF at 130 °C.

Heshmatollah Alinezhad

Research

Abstract