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Heshmatollah Alinezhad

Heshmatollah Alinezhad

Academic rank: Professor
ORCID:
Education: PhD.
ScopusId:
Faculty: Faculty of Chemistry
Address:
Phone: 9111144735

Research

Title
Synthesis and Cytotoxic Evaluation of Novel 1,2,3-Triazole-4-Linked (2E,6E)-2- Benzylidene-6-(4-nitrobenzylidene)cyclohexanones
Type
JournalPaper
Keywords
(E,E)-2-Benzylidene-6-(4-nitrobenzylidene)cyclohexanones, 1,2,3-Triazoles, Click chemistry, Cyclohexanone, Cytotoxic activity.
Year
2016
Journal HELVETICA CHIMICA ACTA
DOI
Researchers Mohammad Mahdavi ، maryam akbari ، Mina Saeedi ، Maryam Karimi ، Niloufar Foroughi ، Elahe K arimpour Razkenari ، Heshmatollah Alinezhad ، Alireza Foroumadi ، Abbas Shafiee ، Tahmineh Akbarzadeh

Abstract

This work describes the synthesis of novel 1,2,3-triazole-4-linked (2E,6E)-2-benzylidene-6-(4-nitrobenzylidene)cyclohexanones starting from cyclohexanone. 1-(Cyclohex-1-en-1-yl)piperidine, the enamine from cyclohexanone and piperidine, reacted with 4-nitrobenzaldehyde to obtain 2-(4-nitrobenzylidene)cyclohexanone. Condensation of the latter compound with (prop-2-yn-1-yloxy)benzaldehyde derivatives under acidic conditions gave (4-nitrobenzylidene)-[(prop-2-yn-1-yloxy)- benzylidene]cyclohexanones. Finally, ‘click reaction’ of these derivatives and various organic azides led to the title compounds. All compounds were examined by MTT assay for cytotoxic activity in one human breast cancer cell line, MDA-MB-231.