1403/01/09
حشمت اله علی نژاد

حشمت اله علی نژاد

مرتبه علمی: استاد
ارکید:
تحصیلات: دکترای تخصصی
اسکاپوس:
دانشکده: دانشکده شیمی
نشانی:
تلفن: 9111144735

مشخصات پژوهش

عنوان
Synthesis and Cytotoxic Evaluation of Novel 1,2,3-Triazole-4-Linked (2E,6E)-2- Benzylidene-6-(4-nitrobenzylidene)cyclohexanones
نوع پژوهش
JournalPaper
کلیدواژه‌ها
(E,E)-2-Benzylidene-6-(4-nitrobenzylidene)cyclohexanones, 1,2,3-Triazoles, Click chemistry, Cyclohexanone, Cytotoxic activity.
سال
2016
مجله HELVETICA CHIMICA ACTA
شناسه DOI
پژوهشگران Mohammad Mahdavi ، maryam akbari ، Mina Saeedi ، Maryam Karimi ، Niloufar Foroughi ، Elahe K arimpour Razkenari ، Heshmatollah Alinezhad ، Alireza Foroumadi ، Abbas Shafiee ، Tahmineh Akbarzadeh

چکیده

This work describes the synthesis of novel 1,2,3-triazole-4-linked (2E,6E)-2-benzylidene-6-(4-nitrobenzylidene)cyclohexanones starting from cyclohexanone. 1-(Cyclohex-1-en-1-yl)piperidine, the enamine from cyclohexanone and piperidine, reacted with 4-nitrobenzaldehyde to obtain 2-(4-nitrobenzylidene)cyclohexanone. Condensation of the latter compound with (prop-2-yn-1-yloxy)benzaldehyde derivatives under acidic conditions gave (4-nitrobenzylidene)-[(prop-2-yn-1-yloxy)- benzylidene]cyclohexanones. Finally, ‘click reaction’ of these derivatives and various organic azides led to the title compounds. All compounds were examined by MTT assay for cytotoxic activity in one human breast cancer cell line, MDA-MB-231.