1403/01/10
حشمت اله علی نژاد

حشمت اله علی نژاد

مرتبه علمی: استاد
ارکید:
تحصیلات: دکترای تخصصی
اسکاپوس:
دانشکده: دانشکده شیمی
نشانی:
تلفن: 9111144735

مشخصات پژوهش

عنوان
Synthesis and structure-activity relationship study of benzofuranbased chalconoids bearing benzylpyridinium moiety as potent acetylcholinesterase inhibitors
نوع پژوهش
JournalPaper
کلیدواژه‌ها
Acetylcholinesterase Alzheimer's disease Benzofuran Docking study Pyridinium
سال
2015
مجله EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
شناسه DOI
پژوهشگران Manizheh Mostofi ، Ghodsi Mohammadi Ziarani ، Mohammad Mahdavi ، Alireza Moradi ، Hamid Nadri ، Saeed Emami ، Heshmatollah Alinezhad ، Alireza Foroumadi ، Abbas Shafiee

چکیده

A series of benzofuran-based chalconoids 6aev were designed and synthesized as new potential AChE inhibitors. The in vitro assay of synthesized compounds 6aev showed that most compounds had significant anti-AChE activity at micromolar or sub-micromolar levels. Among the tested compounds, 3- pyridinium derivative 6m bearing N-(2-bromobenzyl) moiety and 7-methoxy substituent on the benzofuran ring exhibited superior activity. This compound with IC50 value of 0.027 mM was as potent as standard drug donepezil.