The design and fabrication of bio-inspired materials are valuable for the treatment of Parkinson's disease (PD) due to their remarkable antioxidant properties, biocompatibility, and minor side effects. In this study, novel biocompatible and biodegradable chitosan-gelatin-green tea extract (CS-Gel-GTE) composite particles were fabricated with excellent antioxidant properties for therapeutic purposes in PD. An innovative angle-dependent electrospray system fabricated CS-Gel-GTE composite particles in only 1 min using a single-step method. The composite particles were investigated using various characterization methods. In addition to being facile and cost-effective, our methodology resulted in the formation of particles with a prolonged release time of nine days for GTE with a pH of 7.4. A cellular study was also performed to investigate the composite particles' cell viability and neuroprotective effects. The results showed enhanced cell viability and a significant reduction in cell apoptosis. In addition, the synthesized biomaterials showed the potential to inhibit the formation of reactive oxygen species (ROS), increase tyrosine hydroxylase (TH) enzyme expression and decrease α-syn protein expression. Overall, this study offers exquisite natural biomaterials for PD treatment.
