In recent years, a new technique of magnetic dSPE method based on ferrofluids has been introduced to prevent the aggregation of magnetic nanoparticles (MNPs), and improve their dispersibility in the sample solution [1]. Ferrofluids are the stable and uniform suspensions of magnetic nanoparticles that suspends in a carrier liquid [2]. The aim of this study is develop the magnetic dSPE method based on a new ferrofluid for isolation and pre-concentration of Morin in food samples. In this work, a stable ferrofluid was formed by mixing ethylene glycol/tetramethylammonium chloride as deep eutectic solvent (DES) and SiO2@Fe3O4 without any stabilizer. DES increases the dispersibility of the sorbent, and decrease its consumption as well as the extraction time. These solvents as an excellent carrier for ferrofluids have exclusive features such as low-cost and toxicity, biodegradability, high purity, rapid, and simple synthesis process.
